ISSN 0022-3573
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Review Article
Drug-induced block of cardiac HERG potassium channels and development of torsade de pointes arrhythmias: the case of antipsychotics pp. 151-161(11) Authors: Vincenzo Calderone; Lara Testai; Enrica Martinotti; Mario Del Tacca; Maria Cristina Breschi
Research Papers: Pharmaceutics and Drug Delivery
In-vitro evaluation of khaya and albizia gums as compression coatings for drug targeting to the colon pp. 163-168(6) Authors: Oluwatoyin A. Odeku; John T. Fell
Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model pp. 169-175(7) Authors: Majella E. Lane; Caitriona M. O'Driscoll; Owen I. Corrigan
Research Papers: Biopharmaceutics and Drug Disposition
Pharmacokinetic advantage of intraperitoneal injection of docetaxel in the treatment for peritoneal dissemination of cancer in mice pp. 177-181(5) Authors: Tsutomu Shimada; Masaaki Nomura; Koichi Yokogawa; Yoshio Endo; Takuma Sasaki; Ken-ichi Miyamoto; Yutaka Yonemura
A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies pp. 183-189(7) Authors: Lynne Evans; Leon Aarons; Chris Brearley
Research Papers: Molecular and Clinical Pharmacology
Fadolmidine-induced ocular hypotension in normotensive rabbits pp. 191-195(5) Authors: Jouko Savolainen; Riku Niemi; Antti Mäntylä; Juhani Huuskonen; Tomi Järvinen
The changes in the endothelial expression of cell adhesion molecules and iNOS in the vessel wall after the short-term administration of simvastatin in rabbit model of atherosclerosis. pp. 197-203(7) Authors: Petr Nachtigal; Martin Kopecky; Dagmar Solichova; Petr Zdansky; Vladimir Semecky
In-vivo effects of the 1,2,4-piperazine derivatives MM5 and MC1, putative 5-HT agonists, on dopamine and serotonin release in rat prefrontal cortex pp. 205-211(7) Authors: Joanna Iskra-Jopa; Krystyna Goembiowska; Anna Dziubina; Marcin Cybulski; Beata Duszyska; Zdzisaw Chilmonczyk
The metallopeptide antibiotic bacitracin inhibits interleukin-12 and 2 secretion pp. 213-218(6) Authors: I. Alloza; K. Vandenbroeck
Research Papers: Biomedicinal Chemistry
Synthesis of baicalein derivatives as potential anti-aggregatory and anti-inflammatory agents pp. 219-225(7) Authors: Wen-Hsin Huang; An-Rong Lee; Pei-Yu Chien; Tz-Chong Chou
Research Papers: Drugs from Natural Sources
Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats pp. 227-232(6) Authors: Yune-Fang Ueng; Tung-Hu Tsai; Ming-Jaw Don; Ruei-Ming Chen; Ta-Liang Chen
Polyphenols from plants used in traditional Indonesian medicine (Jamu): uptake and antioxidative effects in rat H4IIE hepatoma cells pp. 233-240(8) Authors: Bärbel Steffan; Wim Wätjen; Gudrun Michels; Petra Niering; Victor Wray; Rainer Ebel; RuAngelie Edrada; Regine Kahl; Peter Proksch
Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin pp. 241-246(6) Authors: S. Rajasekaran; K. Sivagnanam; S. Subramanian
Communications
Effects of glucose, fructose and 5-hydroxymethyl-2-furaldehyde on the presystemic metabolism and absorption of glycyrrhizin in rabbits pp. 247-251(5) Authors: Y.C. Hou; H. Ching; P.D.L. Chao; S.Y. Tsai; K.C. Wen; P.H. Hsieh; S.L. Hsiu
The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action pp. 253-257(5) Authors: Ewa Chojnacka-Wójcik; Aleksandra Kodziska; Ewa Tatarczyska
Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect pp. 259-264(6) Authors: Yajun Chen; Jie Liu; Xiangliang Yang; Xiaoling Zhao; Huibi Xu
Gastroprotective activity of a new semi-synthetic solidagenone derivative in mice pp. 265-271(7) Authors: Jaime A. Rodríguez; Cristina Theoduloz; Marianela Sánchez; Tania Yáñez; Iván Razmilic; Guillermo Schmeda-Hirschmann